Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity

MYC and RUNX oncogenes each trigger p53‐mediated failsafe responses when overexpressed in vitro and collaborate with p53 deficiency in vivo. However, together they drive rapid onset lymphoma without mutational loss of p53. This phenomenon was investigated further by transcriptomic analysis of premal...

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Detalles Bibliográficos
Autores principales: Hay, Jodie, Gilroy, Kathryn, Huser, Camille, Kilbey, Anna, Mcdonald, Alma, MacCallum, Amanda, Holroyd, Ailsa, Cameron, Ewan, Neil, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772115/
https://www.ncbi.nlm.nih.gov/pubmed/31257681
http://dx.doi.org/10.1002/jcb.29143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772115/
https://www.ncbi.nlm.nih.gov/pubmed/31257681
http://dx.doi.org/10.1002/jcb.29143

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