Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors

General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyrid...

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Detalles Bibliográficos
Autores principales: Guo, Yafei, Harutyunyan, Syuzanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772156/
https://www.ncbi.nlm.nih.gov/pubmed/31257687
http://dx.doi.org/10.1002/anie.201906237
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author Guo, Yafei
Harutyunyan, Syuzanna R.
author_facet Guo, Yafei
Harutyunyan, Syuzanna R.
author_sort Guo, Yafei
collection PubMed
description General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.
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spelling pubmed-67721562019-10-07 Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors Guo, Yafei Harutyunyan, Syuzanna R. Angew Chem Int Ed Engl Communications General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system. John Wiley and Sons Inc. 2019-07-30 2019-09-09 /pmc/articles/PMC6772156/ /pubmed/31257687 http://dx.doi.org/10.1002/anie.201906237 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Guo, Yafei
Harutyunyan, Syuzanna R.
Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
title Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
title_full Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
title_fullStr Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
title_full_unstemmed Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
title_short Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
title_sort highly enantioselective catalytic addition of grignard reagents to n‐heterocyclic acceptors
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772156/
https://www.ncbi.nlm.nih.gov/pubmed/31257687
http://dx.doi.org/10.1002/anie.201906237
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