Hemozoin produced by mammals confers heme tolerance

Free heme is cytotoxic as exemplified by hemolytic diseases and genetic deficiencies in heme recycling and detoxifying pathways. Thus, intracellular accumulation of heme has not been observed in mammalian cells to date. Here we show that mice deficient for the heme transporter SLC48A1 (also known as...

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Detalles Bibliográficos
Autores principales: Pek, Rini H, Yuan, Xiaojing, Rietzschel, Nicole, Zhang, Jianbing, Jackson, Laurie, Nishibori, Eiji, Ribeiro, Ana, Simmons, William, Jagadeesh, Jaya, Sugimoto, Hiroshi, Alam, Md Zahidul, Garrett, Lisa, Haldar, Malay, Ralle, Martina, Phillips, John D, Bodine, David M, Hamza, Iqbal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773446/
https://www.ncbi.nlm.nih.gov/pubmed/31571584
http://dx.doi.org/10.7554/eLife.49503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773446/
https://www.ncbi.nlm.nih.gov/pubmed/31571584
http://dx.doi.org/10.7554/eLife.49503

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