Kdm6b Regulates Context-Dependent Hematopoietic Stem Cell Self-Renewal and Leukemogenesis

The histone demethylase KDM6B (JMJD3) is upregulated in blood disorders, suggesting it may have important pathogenic functions. Here we examined the function of Kdm6b in hematopoietic stem cells (HSC) to evaluate its potential as a therapeutic target. Loss of Kdm6b lead to depletion of phenotypic an...

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Detalles Bibliográficos
Autores principales: Mallaney, Cates, Ostrander, Elizabeth L., Celik, Hamza, Kramer, Ashley C., Martens, Andrew, Kothari, Alok, Kyun Koh, Won, Haussler, Emily, Iwamori, Naoki, Gontarz, Paul, Zhang, Bo, Challen, Grant A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773521/
https://www.ncbi.nlm.nih.gov/pubmed/30936419
http://dx.doi.org/10.1038/s41375-019-0462-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773521/
https://www.ncbi.nlm.nih.gov/pubmed/30936419
http://dx.doi.org/10.1038/s41375-019-0462-4

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