Cargando…

Kdm6b Regulates Context-Dependent Hematopoietic Stem Cell Self-Renewal and Leukemogenesis

The histone demethylase KDM6B (JMJD3) is upregulated in blood disorders, suggesting it may have important pathogenic functions. Here we examined the function of Kdm6b in hematopoietic stem cells (HSC) to evaluate its potential as a therapeutic target. Loss of Kdm6b lead to depletion of phenotypic an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mallaney, Cates, Ostrander, Elizabeth L., Celik, Hamza, Kramer, Ashley C., Martens, Andrew, Kothari, Alok, Kyun Koh, Won, Haussler, Emily, Iwamori, Naoki, Gontarz, Paul, Zhang, Bo, Challen, Grant A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773521/ https://www.ncbi.nlm.nih.gov/pubmed/30936419 http://dx.doi.org/10.1038/s41375-019-0462-4

Ejemplares similares

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness
por: Ostrander, Elizabeth L., et al.
Publicado: (2020)

Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation
por: Kramer, Ashley C., et al.
Publicado: (2017)

Rare variant analysis of blood pressure phenotypes in the Genetic Analysis Workshop 18 whole genome sequencing data using sequence kernel association test
por: Mallaney, Cates, et al.
Publicado: (2014)

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
por: Jeong, Mira, et al.
Publicado: (2018)

Leukemogenesis via aberrant self‐renewal by the MLL/AEP‐mediated transcriptional activation system
por: Yokoyama, Akihiko
Publicado: (2021)

Role of the MOZ/MLL‐mediated transcriptional activation system for self‐renewal in normal hematopoiesis and leukemogenesis
por: Yokoyama, Akihiko
Publicado: (2021)

The process of leukemogenesis.
por: Irons, R D, et al.
Publicado: (1996)

Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knockin mice
por: Hyde, R. Katherine, et al.
Publicado: (2015)

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition
por: Galland, Ava, et al.
Publicado: (2021)

Cytoplasmic NEAT1 Suppresses AML Stem Cell Self‐Renewal and Leukemogenesis through Inactivation of Wnt Signaling
por: Yan, Huiwen, et al.
Publicado: (2021)

The Philadelphia chromosome in leukemogenesis
por: Kang, Zhi-Jie, et al.
Publicado: (2016)

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis
por: Rasmussen, Kasper D., et al.
Publicado: (2015)

Promiscuous Expression of H2B-GFP Transgene in Hematopoietic Stem Cells
por: Challen, Grant A., et al.
Publicado: (2008)

Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives
por: Bouligny, Ian M., et al.
Publicado: (2023)

STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis
por: Kosan, Christian, et al.
Publicado: (2013)

Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
por: McDonald, James I., et al.
Publicado: (2016)

Leukemogenesis and ageing: ‘fit for transformation’ ?
por: Greaves, Mel
Publicado: (2011)

Granulocyte colony-stimulating factor and leukemogenesis.
por: de Figueiredo, Lorena Lobo, et al.
Publicado: (2004)

Mesenchymal niche: the sensor and effector of leukemogenesis
por: Oh, Il-Hoan
Publicado: (2015)

The Role of TAL1 in Hematopoiesis and Leukemogenesis
por: Vagapova, E. R., et al.
Publicado: (2018)

A Prospective Analysis of Human Leukemogenesis
por: Eaves, Connie J.
Publicado: (2018)

NSD1 in erythroid differentiation and leukemogenesis
por: Tauchmann, Samantha, et al.
Publicado: (2020)

Editorial: Mechanisms of Epigenetics and Genetics in Leukemogenesis
por: Li, Yonghui, et al.
Publicado: (2022)

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
por: Ballabio, Erica, et al.
Publicado: (2012)

Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis
por: Le, Phuong M., et al.
Publicado: (2018)

RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis
por: Zebisch, Armin, et al.
Publicado: (2019)

Bortezomib suppresses self‐renewal and leukemogenesis of leukemia stem cell by NF‐ĸB‐dependent inhibition of CDK6 in MLL‐rearranged myeloid leukemia
por: Zhou, Bin, et al.
Publicado: (2021)

In Vitro Self-Renewal Division of Hematopoietic Stem Cells
por: Ema, Hideo, et al.
Publicado: (2000)

Heterogeneity, Self-Renewal, and Differentiation of Hematopoietic Stem Cells
por: Jurecic, Roland, et al.
Publicado: (2012)

Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis
por: Baum, Karina J, et al.
Publicado: (2008)

Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?
por: Henry, Curtis J., et al.
Publicado: (2011)

PAFc, a Key Player in MLL-rearranged Leukemogenesis
por: Tan, Jiaying, et al.
Publicado: (2010)

Leukemogenesis Induced by an Activating β-catenin mutation in Osteoblasts
por: Kode, Aruna, et al.
Publicado: (2014)

Identifying new targets in leukemogenesis using computational approaches
por: Jayaraman, Archana, et al.
Publicado: (2015)

Quaking and miR-155 interactions in inflammation and leukemogenesis
por: Tili, Esmerina, et al.
Publicado: (2015)

PML nuclear body biogenesis and oligomerization-driven leukemogenesis
por: Li, Yuwen, et al.
Publicado: (2020)

TET2 deficiency promotes MDS-associated leukemogenesis
por: Huang, Feiteng, et al.
Publicado: (2022)

Smad4 is critical for self-renewal of hematopoietic stem cells
por: Karlsson, Göran, et al.
Publicado: (2007)

TSNAXIP1 is required for sperm head formation and male fertility
por: Sultana, Tasrin, et al.
Publicado: (2023)

RelB-Dependent Stromal Cells Promote T-Cell Leukemogenesis
por: dos Santos, Nuno R., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_44cml2pmv87ggmghr72pc6ggh5