NUMT Confounding Biases Mitochondrial Heteroplasmy Calls in Favor of the Reference Allele

Homology between mitochondrial DNA (mtDNA) and nuclear DNA of mitochondrial origin (nuMTs) causes confounding when aligning short sequence reads to the reference human genome, as the true sequence origin cannot be determined. Using a systematic in silico approach, we here report the impact of all po...

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Detalles Bibliográficos
Autores principales: Maude, Hannah, Davidson, Mira, Charitakis, Natalie, Diaz, Leo, Bowers, William H. T., Gradovich, Eva, Andrew, Toby, Huntley, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773831/
https://www.ncbi.nlm.nih.gov/pubmed/31612134
http://dx.doi.org/10.3389/fcell.2019.00201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773831/
https://www.ncbi.nlm.nih.gov/pubmed/31612134
http://dx.doi.org/10.3389/fcell.2019.00201

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