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NUMT Confounding Biases Mitochondrial Heteroplasmy Calls in Favor of the Reference Allele
Homology between mitochondrial DNA (mtDNA) and nuclear DNA of mitochondrial origin (nuMTs) causes confounding when aligning short sequence reads to the reference human genome, as the true sequence origin cannot be determined. Using a systematic in silico approach, we here report the impact of all po...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773831/ https://www.ncbi.nlm.nih.gov/pubmed/31612134 http://dx.doi.org/10.3389/fcell.2019.00201 |