The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential role in protecting cell viability through modulation of oxidative stress. TRPM2 is highly expressed in cancer. When TRPM2 is inhibited, mitochondria are dysfunctional, ROS levels are increased, and cell viabi...

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Detalles Bibliográficos
Autores principales: Bao, Lei, Festa, Fernanda, Freet, Christopher S., Lee, John P., Hirschler-Laszkiewicz, Iwona M., Chen, Shu-jen, Keefer, Kerry A., Wang, Hong-Gang, Patterson, Andrew D., Cheung, Joseph Y., Miller, Barbara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773863/
https://www.ncbi.nlm.nih.gov/pubmed/31575956
http://dx.doi.org/10.1038/s41598-019-50661-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773863/
https://www.ncbi.nlm.nih.gov/pubmed/31575956
http://dx.doi.org/10.1038/s41598-019-50661-8

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