Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP(2) Suggest a Mechanism for Regulation

TRPM8 is a member of the transient receptor potential ion channel family where it functions as a cold and pain sensor in humans and other higher organisms. Previous studies show that TRPM8 requires the signaling phosphoinositide lipid PIP(2) to function. TRPM8 function is further regulated by other...

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Detalles Bibliográficos
Autores principales: Sisco, Nicholas J., Helsell, Cole V. M., Van Horn, Wade D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773951/
https://www.ncbi.nlm.nih.gov/pubmed/31575973
http://dx.doi.org/10.1038/s41598-019-49912-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773951/
https://www.ncbi.nlm.nih.gov/pubmed/31575973
http://dx.doi.org/10.1038/s41598-019-49912-5

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