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Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound that was originally designed as kinase inhibitor...

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Detalles Bibliográficos
Autores principales: Grathwol, Christoph W, Wössner, Nathalie, Swyter, Sören, Smith, Adam C, Tapavicza, Enrico, Hofstetter, Robert K, Bodtke, Anja, Jung, Manfred, Link, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774072/
https://www.ncbi.nlm.nih.gov/pubmed/31598174
http://dx.doi.org/10.3762/bjoc.15.214