Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments

SHANK3 (ProSAP2) is among the most common genes mutated in autism spectrum disorders (ASD) and is the causative gene in Phelan–McDermid syndrome (PMS). We performed genetic rescue of Shank3 mutant phenotypes in adult mice expressing a Shank3 exon 21 insertion mutation (Shank3(G)). We used a tamoxife...

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Detalles Bibliográficos
Autores principales: Speed, Haley E., Kouser, Mehreen, Xuan, Zhong, Liu, Shunan, Duong, Anne, Powell, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774147/
https://www.ncbi.nlm.nih.gov/pubmed/31451607
http://dx.doi.org/10.1523/ENEURO.0317-19.2019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774147/
https://www.ncbi.nlm.nih.gov/pubmed/31451607
http://dx.doi.org/10.1523/ENEURO.0317-19.2019

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