Structural mechanism for NEK7-licensed NLRP3 inflammasome activation

The NLRP3 inflammasome can be activated by diverse stimuli, including nigericin, uric acid crystals, amyloid-β fibrils, and extracellular ATP. The mitotic kinase NEK7 licenses NLRP3 inflammasome assembly and activation in the interphase. Here we report a 3.8-Å cryo-electron microscopy structure of i...

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Detalles Bibliográficos
Autores principales: Sharif, Humayun, Wang, Li, Wang, Wei Li, Magupalli, Venkat Giri, Andreeva, Liudmila, Qiao, Qi, Hauenstein, Arthur V., Wu, Zhaolong, Nunez, Gabriel, Mao, Youdong, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774351/
https://www.ncbi.nlm.nih.gov/pubmed/31189953
http://dx.doi.org/10.1038/s41586-019-1295-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774351/
https://www.ncbi.nlm.nih.gov/pubmed/31189953
http://dx.doi.org/10.1038/s41586-019-1295-z

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