Cargando…

LRRK2 and membrane trafficking: nexus of Parkinson’s disease

Recent evidence from genetics, animal model systems and biochemical studies suggests that defects in membrane trafficking play an important part in the pathophysiology of Parkinson’s disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) constitute the most frequent genetic cause of both fa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hur, Eun-Mi, Jang, Eun-Hae, Jeong, Ga Ram, Lee, Byoung Dae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2019
Materias:	Invited Mini Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774422/ https://www.ncbi.nlm.nih.gov/pubmed/31383252 http://dx.doi.org/10.5483/BMBRep.2019.52.9.186

Ejemplares similares

Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson’s disease and beyond
por: Bae, Jae Ryul, et al.
Publicado: (2015)

LRRK2 at the Crossroad of Aging and Parkinson’s Disease
por: Hur, Eun-Mi, et al.
Publicado: (2021)

Pathological Functions of LRRK2 in Parkinson’s Disease
por: Jeong, Ga Ram, et al.
Publicado: (2020)

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
por: Jeong, Ga Ram, et al.
Publicado: (2018)

Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease
por: Yoo, Hajung, et al.
Publicado: (2022)

Precise control of mitophagy through ubiquitin proteasome system and deubiquitin proteases and their dysfunction in Parkinson’s disease
por: Park, Ga Hyun, et al.
Publicado: (2021)

Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
por: Bang, EunJin, et al.
Publicado: (2019)

Plant cell culture strategies for the production of natural products
por: Ochoa-Villarreal, Marisol, et al.
Publicado: (2016)

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease
por: Iovino, Ludovica, et al.
Publicado: (2022)

MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation
por: Lee, Juneyoung, et al.
Publicado: (2016)

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
por: Byun, Hae-Ok, et al.
Publicado: (2015)

MiR-146 and miR-125 in the regulation of innate immunity and inflammation
por: Lee, Hye-Mi, et al.
Publicado: (2016)

Ubiquitin E3 ligases in cancer: somatic mutation and amplification
por: Jo, Eun-Hye, et al.
Publicado: (2023)

Glyco-engineering strategies for the development of therapeutic enzymes with improved efficacy for the treatment of lysosomal storage diseases
por: Oh, Doo-Byoung
Publicado: (2015)

Physiological functions of the TRPM4 channels via protein interactions
por: Cho, Chang-Hoon, et al.
Publicado: (2015)

Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2
por: Kim, Myung-Jin, et al.
Publicado: (2017)

Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases
por: Bang, Oh Young, et al.
Publicado: (2022)

Patient-specific pluripotent stem cell-based Parkinson’s disease models showing endogenous alpha-synuclein aggregation
por: Oh, Yohan
Publicado: (2019)

The central regulator p62 between ubiquitin proteasome system and autophagy and its role in the mitophagy and Parkinson’s disease
por: Shin, Woo Hyun, et al.
Publicado: (2020)

Substrate specificity of bacterial endoribonuclease toxins
por: Han, Yoontak, et al.
Publicado: (2020)

Parallel mechanisms for direct and indirect membrane protein trafficking by synucleins
por: Oaks, Adam W, et al.
Publicado: (2013)

Extracellular matrixes and neuroinflammation
por: Jang, Dong Gil, et al.
Publicado: (2020)

Traction force microscopy for understanding cellular mechanotransduction
por: Hur, Sung Sik, et al.
Publicado: (2020)

MicroRNAs: promising biomarkers for diagnosis and therapeutic targets in human colorectal cancer metastasis
por: Hur, Keun
Publicado: (2015)

With the greatest care, stromal interaction molecule (STIM) proteins verify what skeletal muscle is doing
por: Cho, Chung-Hyun, et al.
Publicado: (2018)

Roles of heterogenous hepatic macrophages in the progression of liver diseases
por: Lee, Kyeong-Jin, et al.
Publicado: (2022)

DNA methylation-based age prediction from various tissues and body fluids
por: Jung, Sang-Eun, et al.
Publicado: (2017)

Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
por: Lee, Byoung Dae, et al.
Publicado: (2010)

Development of CRISPR technology for precise single-base genome editing: a brief review
por: Lee, Hyomin K., et al.
Publicado: (2021)

2-Undecanone derived from Pseudomonas aeruginosa modulates the neutrophil activity
por: Jeong, Yu Sun, et al.
Publicado: (2022)

Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans
por: Kwon, Sujeong, et al.
Publicado: (2018)

Untold story of human cervical cancers: HPV-negative cervical cancer
por: Lee, Jae-Eun, et al.
Publicado: (2022)

Odorant receptors in cancer
por: Chung, Chan, et al.
Publicado: (2022)

Membrane remodeling properties of the Parkinson’s disease protein LRRK2
por: Wang, Xinbo, et al.
Publicado: (2023)

Update of early phase clinical trials in cancer immunotherapy
por: Lee, Dae Ho
Publicado: (2021)

Tiny dancers: the integrin–growth factor nexus in angiogenic signaling
por: Smyth, Susan S., et al.
Publicado: (2002)

Pseudomonadota in the oral cavity: a glimpse into the environment-human nexus
por: Leão, Inês, et al.
Publicado: (2022)

Epigenetic memory in gene regulation and immune response
por: Kim, Min Young, et al.
Publicado: (2019)

Cancer immunotherapy with T-cell targeting cytokines: IL-2 and IL-7
por: Kim, Ji-Hae, et al.
Publicado: (2021)

Implications of NQO1 in cancer therapy
por: Oh, Eun-Taex, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vff45dmalmb2n3aceev7b5pvqi