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Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications

RNA contains various chemical modifications, among which N6-methyladenosine (m6A) is the most prevalent modified nucleotide in eukaryotic mRNA. Emerging evidence suggests that m6A plays an important role in regulating a variety of cellular functions by controlling mRNA processing, translation and de...

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Detalles Bibliográficos
Autores principales: Matsuzawa, Shun, Wakata, Yuka, Ebi, Fumiya, Isobe, Masaharu, Kurosawa, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774519/
https://www.ncbi.nlm.nih.gov/pubmed/31577817
http://dx.doi.org/10.1371/journal.pone.0223197