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RNA binding activates RIG-I by releasing an autorepressed signaling domain
The retinoic acid–inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty dis...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774723/ https://www.ncbi.nlm.nih.gov/pubmed/31616790 http://dx.doi.org/10.1126/sciadv.aax3641 |