RNA binding activates RIG-I by releasing an autorepressed signaling domain

The retinoic acid–inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty dis...

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Detalles Bibliográficos
Autores principales: Dickey, T. H., Song, B., Pyle, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774723/
https://www.ncbi.nlm.nih.gov/pubmed/31616790
http://dx.doi.org/10.1126/sciadv.aax3641

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