Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain. PS1/γ-secretase mediates axon growth by inhibiting Rho...

Descripción completa

Detalles Bibliográficos
Autores principales: Javier-Torrent, Míriam, Marco, Sergi, Rocandio, Daniel, Pons-Vizcarra, Maria, Janes, Peter W, Lackmann, Martin, Egea, Joaquim, Saura, Carlos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774734/
https://www.ncbi.nlm.nih.gov/pubmed/31577226
http://dx.doi.org/10.7554/eLife.43646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774734/
https://www.ncbi.nlm.nih.gov/pubmed/31577226
http://dx.doi.org/10.7554/eLife.43646

Ejemplares similares