Structure of the dynein-2 complex and its assembly with intraflagellar transport trains

Dynein-2 assembles with polymeric intraflagellar transport (IFT) trains to form a transport machinery crucial for cilia biogenesis and signaling. Here we recombinantly expressed the ~1.4 MDa human dynein-2 complex and solved its cryo-EM structure to near-atomic resolution. The two identical copies o...

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Detalles Bibliográficos
Autores principales: Toropova, Katerina, Zalyte, Ruta, Mukhopadhyay, Aakash G., Mladenov, Miroslav, Carter, Andrew P., Roberts, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774794/
https://www.ncbi.nlm.nih.gov/pubmed/31451806
http://dx.doi.org/10.1038/s41594-019-0286-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774794/
https://www.ncbi.nlm.nih.gov/pubmed/31451806
http://dx.doi.org/10.1038/s41594-019-0286-y

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