The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B(6) salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and increas...

Descripción completa

Detalles Bibliográficos
Autores principales: Mascolo, Elisa, Barile, Anna, Mecarelli, Lorenzo Stufera, Amoroso, Noemi, Merigliano, Chiara, Massimi, Arianna, Saggio, Isabella, Hansen, Torben, Tramonti, Angela, Di Salvo, Martino Luigi, Barbetti, Fabrizio, Contestabile, Roberto, Vernì, Fiammetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775053/
https://www.ncbi.nlm.nih.gov/pubmed/31578392
http://dx.doi.org/10.1038/s41598-019-50673-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775053/
https://www.ncbi.nlm.nih.gov/pubmed/31578392
http://dx.doi.org/10.1038/s41598-019-50673-4

Ejemplares similares