Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots

G-protein coupled receptors (GPCRs) play a pivotal role in transmitting signals at the cellular level. Structural insights can be exploited to support GPCR structure-based drug discovery endeavours. Despite advances in GPCR crystallography, active state structures are scarce. Molecular dynamics (MD)...

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Detalles Bibliográficos
Autores principales: Lovera, Silvia, Cuzzolin, Alberto, Kelm, Sebastian, De Fabritiis, Gianni, Sands, Zara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775061/
https://www.ncbi.nlm.nih.gov/pubmed/31578448
http://dx.doi.org/10.1038/s41598-019-50752-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775061/
https://www.ncbi.nlm.nih.gov/pubmed/31578448
http://dx.doi.org/10.1038/s41598-019-50752-6

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