Time origin and structural analysis of the induced CRISPR/cas9 megabase-sized deletions and duplications involving the Cntn6 gene in mice

In a previous study using one-step CRISPR/Cas9 genome editing in mouse zygotes, we created five founders carrying a 1,137 kb deletion and two founders carrying the same deletion, plus a 2,274 kb duplication involving the Cntn6 gene (encoding contactin-6). Using these mice, the present study had the...

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Detalles Bibliográficos
Autores principales: Pristyazhnyuk, Inna E., Minina, Julia, Korablev, Alexey, Serova, Irina, Fishman, Veniamin, Gridina, Maria, Rozhdestvensky, Timofey S., Gubar, Leonid, Skryabin, Boris V., Serov, Oleg L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775113/
https://www.ncbi.nlm.nih.gov/pubmed/31578377
http://dx.doi.org/10.1038/s41598-019-50649-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775113/
https://www.ncbi.nlm.nih.gov/pubmed/31578377
http://dx.doi.org/10.1038/s41598-019-50649-4

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