Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment of endogenously expressed protein kinases from cell lines and tissues. These beads enable chemoproteomics profiling of kinase inhibitors of interest in dose-dependent competition stud...

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Detalles Bibliográficos
Autores principales: Eberl, H. Christian, Werner, Thilo, Reinhard, Friedrich B., Lehmann, Stephanie, Thomson, Douglas, Chen, Peiling, Zhang, Cunyu, Rau, Christina, Muelbaier, Marcel, Drewes, Gerard, Drewry, David, Bantscheff, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775116/
https://www.ncbi.nlm.nih.gov/pubmed/31578349
http://dx.doi.org/10.1038/s41598-019-50335-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775116/
https://www.ncbi.nlm.nih.gov/pubmed/31578349
http://dx.doi.org/10.1038/s41598-019-50335-5

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