GM2-GM3 gangliosides ratio is dependent on GRP94 through down-regulation of GM2-AP cofactor in brain metastasis cells

GRP94 is an ATP-dependent chaperone able to regulate pro-oncogenic signaling pathways. Previous studies have shown a critical role of GRP94 in brain metastasis (BrM) pathogenesis and progression. In this work, an untargeted lipidomic analysis revealed that some lipid species were altered in GRP94-de...

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Detalles Bibliográficos
Autores principales: Bedia, Carmen, Badia, Miriam, Muixí, Laia, Levade, Thierry, Tauler, Romà, Sierra, Angels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775165/
https://www.ncbi.nlm.nih.gov/pubmed/31578452
http://dx.doi.org/10.1038/s41598-019-50761-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775165/
https://www.ncbi.nlm.nih.gov/pubmed/31578452
http://dx.doi.org/10.1038/s41598-019-50761-5

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