RNA Transcription and Splicing Errors as a Source of Cancer Frameshift Neoantigens for Vaccines

The success of checkpoint inhibitors in cancer therapy is largely attributed to activating the patient’s immune response to their tumor’s neoantigens arising from DNA mutations. This realization has motivated the interest in personal cancer vaccines based on sequencing the patient’s tumor DNA to dis...

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Detalles Bibliográficos
Autores principales: Shen, Luhui, Zhang, Jian, Lee, HoJoon, Batista, Milene Tavares, Johnston, Stephen Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775166/
https://www.ncbi.nlm.nih.gov/pubmed/31578439
http://dx.doi.org/10.1038/s41598-019-50738-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775166/
https://www.ncbi.nlm.nih.gov/pubmed/31578439
http://dx.doi.org/10.1038/s41598-019-50738-4

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