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RNA Transcription and Splicing Errors as a Source of Cancer Frameshift Neoantigens for Vaccines
The success of checkpoint inhibitors in cancer therapy is largely attributed to activating the patient’s immune response to their tumor’s neoantigens arising from DNA mutations. This realization has motivated the interest in personal cancer vaccines based on sequencing the patient’s tumor DNA to dis...
Autores principales: | Shen, Luhui, Zhang, Jian, Lee, HoJoon, Batista, Milene Tavares, Johnston, Stephen Albert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775166/ https://www.ncbi.nlm.nih.gov/pubmed/31578439 http://dx.doi.org/10.1038/s41598-019-50738-4 |
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