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Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

[Image: see text] TAR DNA-binding protein 43 (TDP-43) has been identified as the major constituent of the proteinaceous inclusions that are characteristic of most forms of amyotrophic lateral sclerosis (ALS) and ubiquitin positive frontotemporal lobar degeneration (FTLD). Wild type TDP-43 inclusions...

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Detalles Bibliográficos
Autores principales: Ng, Janice S. W., Hanspal, Maya A., Matharu, Naunehal S., Barros, Teresa P., Esbjörner, Elin K., Wilson, Mark R., Yerbury, Justin J., Dobson, Christopher M., Kumita, Janet R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775541/
https://www.ncbi.nlm.nih.gov/pubmed/31529970
http://dx.doi.org/10.1021/acs.biochem.9b00592