Defining subpopulations of differential drug response to reveal novel target populations

Personalised medicine has predominantly focused on genetically altered cancer genes that stratify drug responses, but there is a need to objectively evaluate differential pharmacology patterns at a subpopulation level. Here, we introduce an approach based on unsupervised machine learning to compare...

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Detalles Bibliográficos
Autores principales: Keshava, Nirmal, Toh, Tzen S., Yuan, Haobin, Yang, Bingxun, Menden, Michael P., Wang, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776548/
https://www.ncbi.nlm.nih.gov/pubmed/31602313
http://dx.doi.org/10.1038/s41540-019-0113-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776548/
https://www.ncbi.nlm.nih.gov/pubmed/31602313
http://dx.doi.org/10.1038/s41540-019-0113-4

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