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Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway

Interleukin (IL)-37, a pivotal anti-inflammatory cytokine and a fundamental inhibitor of innate immunity, has recently been shown to be abnormally expressed in several autoimmune-related orthopedic diseases, including rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. However, the role...

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Detalles Bibliográficos
Autores principales: Ye, Chenyi, Zhang, Wei, Hang, Kai, Chen, Mo, Hou, Weiduo, Chen, Jianzhong, Chen, Xi, Chen, Erman, Tang, Lan, Lu, Jinwei, Ding, Qianhai, Jiang, Guangyao, Hong, Baojian, He, Rongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776644/
https://www.ncbi.nlm.nih.gov/pubmed/31582734
http://dx.doi.org/10.1038/s41419-019-1904-7