CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis

The molecular mechanism of intervertebral disc degeneration (IVDD) remains unclear. This study aimed to investigate the role of circular RNAs (circRNAs) in the pathogenesis of IVDD. We sued nucleus pulposus (NP) tissues of patients, tert-butyl hydroperoxide (TBHP) stimulated NP cells (NPCs), and IVD...

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Detalles Bibliográficos
Autores principales: Xie, Lin, Huang, Weibo, Fang, Zhenhua, Ding, Fan, Zou, Fei, Ma, Xiaosheng, Tao, Jie, Guo, Jingkang, Xia, Xinlei, Wang, Hongli, Yu, Zuochong, Lu, Feizhou, Jiang, Jianyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776655/
https://www.ncbi.nlm.nih.gov/pubmed/31582722
http://dx.doi.org/10.1038/s41419-019-1978-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776655/
https://www.ncbi.nlm.nih.gov/pubmed/31582722
http://dx.doi.org/10.1038/s41419-019-1978-2

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