Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish

The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and depending on the species, mild to strong vestibular deficits. While studies in mouse models suggest a role for otoferlin in synaptic vesicle exocytosis and endocytosis, it is...

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Detalles Bibliográficos
Autores principales: Manchanda, Aayushi, Chatterjee, Paroma, Bonventre, Josephine A., Haggard, Derik E., Kindt, Katie S., Tanguay, Robert L., Johnson, Colin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776657/
https://www.ncbi.nlm.nih.gov/pubmed/31582816
http://dx.doi.org/10.1038/s41598-019-50710-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776657/
https://www.ncbi.nlm.nih.gov/pubmed/31582816
http://dx.doi.org/10.1038/s41598-019-50710-2

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