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Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes

Metastatic outcomes depend on the interactions of metastatic cells with a specific organ microenvironment. Our previous studies have shown that triple-negative breast cancer (TNBC) MDA-MB-231 cells passaged in astrocyte-conditioned medium (ACM) show proclivity to form brain metastases, but the under...

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Detalles Bibliográficos
Autores principales: Gong, Xianghui, Hou, Zhimin, Endsley, Michael P., Gronseth, Emily I., Rarick, Kevin R., Jorns, Julie M., Yang, Qiuhui, Du, Zhenggui, Yan, Ke, Bordas, Michelle L., Gershan, Jill, Deepak, Parashar, Geethadevi, Anjali, Chaluvally-Raghavan, Pradeep, Fan, Yubo, Harder, David R., Ramchandran, Ramani, Wang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776663/
https://www.ncbi.nlm.nih.gov/pubmed/31602400
http://dx.doi.org/10.1038/s41698-019-0094-1