Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes

Epigenetic regulators are often hijacked by cancer cells to sustain malignant phenotypes. How cells repurpose key regulators of cell identity as tumour‐promoting factors is unclear. The antithetic role of the Polycomb component EZH2 in normal brain and glioma provides a paradigm to dissect how wild‐...

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Detalles Bibliográficos
Autores principales: Mortimer, Thomas, Wainwright, Elanor N, Patel, Harshil, Siow, Bernard M, Jaunmuktane, Zane, Brandner, Sebastian, Scaffidi, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776892/
https://www.ncbi.nlm.nih.gov/pubmed/31468686
http://dx.doi.org/10.15252/embr.201948155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776892/
https://www.ncbi.nlm.nih.gov/pubmed/31468686
http://dx.doi.org/10.15252/embr.201948155

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