Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking

The structure of a 22-base-pair RNA helix with mismatched pyrimidine base pairs is reported. The helix contains two symmetry-related CUG sequences: a triplet-repeat motif implicated in myotonic dystrophy type 1. The CUG repeat contains a U–U mismatch sandwiched between Watson–Crick pairs. Additional...

Descripción completa

Detalles Bibliográficos
Autores principales: Montemayor, Eric J., Virta, Johanna M., Hagler, Lauren D., Zimmerman, Steven C., Butcher, Samuel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777134/
https://www.ncbi.nlm.nih.gov/pubmed/31584014
http://dx.doi.org/10.1107/S2053230X19012172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777134/
https://www.ncbi.nlm.nih.gov/pubmed/31584014
http://dx.doi.org/10.1107/S2053230X19012172

Ejemplares similares