Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis
Sustained virological response (SVR) in hepatitis C virus (HCV) patients treated with pegylated interferon α-2a and ribavirin is associated with reduced insulin resistance (IR), measured as a reduction of homeostasis model assessment (HOMA) scores after 24 weeks of therapy, and reduced fasting serum...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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D.A. Spandidos
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777273/ https://www.ncbi.nlm.nih.gov/pubmed/31602234 http://dx.doi.org/10.3892/etm.2019.7995 |
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author | Hu, Jing-Hong Chang, Ming-Ling Liu, Nai-Jen Yeh, Chau-Ting Huang, Tung-Jung |
author_facet | Hu, Jing-Hong Chang, Ming-Ling Liu, Nai-Jen Yeh, Chau-Ting Huang, Tung-Jung |
author_sort | Hu, Jing-Hong |
collection | PubMed |
description | Sustained virological response (SVR) in hepatitis C virus (HCV) patients treated with pegylated interferon α-2a and ribavirin is associated with reduced insulin resistance (IR), measured as a reduction of homeostasis model assessment (HOMA) scores after 24 weeks of therapy, and reduced fasting serum insulin and serum glucose levels. The present meta-analysis aimed to evaluate the effect of HCV treatment response on IR in HCV patients who achieved SVR and those who did not (non-SVR) after receiving interferon (IFN)-based therapy. The PubMed, Cochrane and Embase databases were searched using combinations of the following search terms: ‘HCV’, ‘hepatitis C’, ‘interferon’, ‘antiviral’, ‘treatment response’ and ‘insulin resistance’. The incidence of IR, HOMA-IR and HOMA-β, as well as fasting glucose and fasting insulin levels, were summarized in terms of basal values and values after the end of treatment for each study. A total of 8 studies were included in the final analysis. There was no significant difference in the reduction in IR between the SVR and non-SVR groups (odds ratio, 0.995; 95% CI=0.613–1.616; P=0.984). However, the SVR group had a significantly higher mean reduction in HOMA-IR (difference in means=−0.485; 95%CI=−0.713 to −0.256; P<0.001) and HOMA-β (difference in means=−15.448; 95%CI=−23.326 to −7.570; P<0.001) compared to the non-SVR group. In conclusion, HCV patients who achieved SVR after IFN-based therapy exhibited improvement in HOMA-IR and HOMA-β. The present results suggest that clinical management of IR and serum glucose levels may be an important way to impact the therapeutic response in HCV patients. |
format | Online Article Text |
id | pubmed-6777273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-67772732019-10-10 Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis Hu, Jing-Hong Chang, Ming-Ling Liu, Nai-Jen Yeh, Chau-Ting Huang, Tung-Jung Exp Ther Med Articles Sustained virological response (SVR) in hepatitis C virus (HCV) patients treated with pegylated interferon α-2a and ribavirin is associated with reduced insulin resistance (IR), measured as a reduction of homeostasis model assessment (HOMA) scores after 24 weeks of therapy, and reduced fasting serum insulin and serum glucose levels. The present meta-analysis aimed to evaluate the effect of HCV treatment response on IR in HCV patients who achieved SVR and those who did not (non-SVR) after receiving interferon (IFN)-based therapy. The PubMed, Cochrane and Embase databases were searched using combinations of the following search terms: ‘HCV’, ‘hepatitis C’, ‘interferon’, ‘antiviral’, ‘treatment response’ and ‘insulin resistance’. The incidence of IR, HOMA-IR and HOMA-β, as well as fasting glucose and fasting insulin levels, were summarized in terms of basal values and values after the end of treatment for each study. A total of 8 studies were included in the final analysis. There was no significant difference in the reduction in IR between the SVR and non-SVR groups (odds ratio, 0.995; 95% CI=0.613–1.616; P=0.984). However, the SVR group had a significantly higher mean reduction in HOMA-IR (difference in means=−0.485; 95%CI=−0.713 to −0.256; P<0.001) and HOMA-β (difference in means=−15.448; 95%CI=−23.326 to −7.570; P<0.001) compared to the non-SVR group. In conclusion, HCV patients who achieved SVR after IFN-based therapy exhibited improvement in HOMA-IR and HOMA-β. The present results suggest that clinical management of IR and serum glucose levels may be an important way to impact the therapeutic response in HCV patients. D.A. Spandidos 2019-11 2019-09-11 /pmc/articles/PMC6777273/ /pubmed/31602234 http://dx.doi.org/10.3892/etm.2019.7995 Text en Copyright: © Hu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Hu, Jing-Hong Chang, Ming-Ling Liu, Nai-Jen Yeh, Chau-Ting Huang, Tung-Jung Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis |
title | Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis |
title_full | Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis |
title_fullStr | Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis |
title_full_unstemmed | Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis |
title_short | Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis |
title_sort | effect of hcv treatment response on insulin resistance: a systematic review and meta-analysis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777273/ https://www.ncbi.nlm.nih.gov/pubmed/31602234 http://dx.doi.org/10.3892/etm.2019.7995 |
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