Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR

Background: Oleanolic acid (OA) and its isomer ursolic acid (UA) have recently emerged as research foci based on their biologic activities. We previously demonstrated that UA can inhibit the activities of UGT1A3 and UGT1A4, and OA inhibits UGT1A3 activity in liver microsomes. However, whether OA and...

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Detalles Bibliográficos
Autores principales: Yao, Na, Zeng, Caiwen, Zhan, Tao, He, Fang, Liu, Mingyi, Liu, Fanglan, Zhang, Hong, Xiong, Yuqing, Xia, Chunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777376/
https://www.ncbi.nlm.nih.gov/pubmed/31611795
http://dx.doi.org/10.3389/fphar.2019.01111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777376/
https://www.ncbi.nlm.nih.gov/pubmed/31611795
http://dx.doi.org/10.3389/fphar.2019.01111

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