Antisense oligonucleotides extend survival of prion-infected mice

Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals caused by conversion of cellular prion protein (PrP(C)) into a self-propagating neurotoxic conformer (prions; PrP(Sc)). Strong genetic proofs of concept support lowering PrP expression as a therapeutic strategy...

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Detalles Bibliográficos
Autores principales: Raymond, Gregory J., Zhao, Hien Tran, Race, Brent, Raymond, Lynne D., Williams, Katie, Swayze, Eric E., Graffam, Samantha, Le, Jason, Caron, Tyler, Stathopoulos, Jacquelyn, O’Keefe, Rhonda, Lubke, Lori L., Reidenbach, Andrew G., Kraus, Allison, Schreiber, Stuart L., Mazur, Curt, Cabin, Deborah E., Carroll, Jeffrey B., Minikel, Eric Vallabh, Kordasiewicz, Holly, Caughey, Byron, Vallabh, Sonia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777807/
https://www.ncbi.nlm.nih.gov/pubmed/31361599
http://dx.doi.org/10.1172/jci.insight.131175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777807/
https://www.ncbi.nlm.nih.gov/pubmed/31361599
http://dx.doi.org/10.1172/jci.insight.131175

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