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Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway

Suppressor of Hairless [Su(H)], the transcription factor at the end of the Notch pathway in Drosophila, utilizes the Hairless protein to recruit two co-repressors, Groucho (Gro) and C-terminal Binding Protein (CtBP), indirectly. Hairless is present only in the Pancrustacea, raising the question of h...

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Detalles Bibliográficos
Autores principales: Miller, Steven W, Movsesyan, Artem, Zhang, Sui, Fernández, Rosa, Posakony, James W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777938/
https://www.ncbi.nlm.nih.gov/pubmed/31545167
http://dx.doi.org/10.7554/eLife.48115