CtBP—a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma

Ctbp2 is a uniquely targetable oncogenic transcriptional coregulator, exhibiting overexpression in most common solid tumors, and critical to the tumor-initiating cell (TIC) transcriptional program. In the “CKP” mouse pancreatic ductal adenocarcinoma (PDAC) model driven by mutant K-Ras, Ctbp2 haploin...

Descripción completa

Detalles Bibliográficos
Autores principales: Chawla, Ayesha T., Chougoni, Kranthi Kumar, Joshi, Prashant J., Cororaton, Agnes D., Memari, Patrick, Stansfield, John C., Park, Haemin, Seth, Rashmi, Szomju, Barbara, Sima, Adam P., Idowu, Michael O., Ellis, Keith C., Grossman, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778071/
https://www.ncbi.nlm.nih.gov/pubmed/31586042
http://dx.doi.org/10.1038/s41389-019-0163-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778071/
https://www.ncbi.nlm.nih.gov/pubmed/31586042
http://dx.doi.org/10.1038/s41389-019-0163-x

Ejemplares similares