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Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing
The selective regulation of bacteria in complex microbial populations is key to controlling pathogenic bacteria. CRISPR nucleases can be programmed to kill bacteria, but require an efficient and broad-host range delivery system to be effective. Here, using an Escherichia coli and Salmonella enterica...
Autores principales: | Hamilton, Thomas A., Pellegrino, Gregory M., Therrien, Jasmine A., Ham, Dalton T., Bartlett, Peter C., Karas, Bogumil J., Gloor, Gregory B., Edgell, David R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778077/ https://www.ncbi.nlm.nih.gov/pubmed/31586051 http://dx.doi.org/10.1038/s41467-019-12448-3 |
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