Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities. One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation. This function is in turn controlled by the cell fate determinant NU...

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Detalles Bibliográficos
Autores principales: Confalonieri, Stefano, Colaluca, Ivan Nicola, Basile, Andrea, Pece, Salvatore, Di Fiore, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2019
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778778/
https://www.ncbi.nlm.nih.gov/pubmed/31451549
http://dx.doi.org/10.1534/g3.119.400494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778778/
https://www.ncbi.nlm.nih.gov/pubmed/31451549
http://dx.doi.org/10.1534/g3.119.400494

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