Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods

Naoxintong capsule (NXT), a prescribed Chinese medicine, has been used clinically for more than 20 years and is widely received by patients. We determined five probe drugs, namely, omeprazole (CYP2C19), midazolam (CYP3A4), phenacetin (CYP1A2), tolbutamide (CYP2C9), and dextromethorphan (CYP2D6) to s...

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Detalles Bibliográficos
Autores principales: Ouyang, Huizi, Shen, Jiayuan, Huang, Xuhua, Ma, Wenjuan, Jia, Qi, Yao, Guangzhe, Tang, Zhidan, Zhang, Dandan, Sun, Mengjie, Teye Azietaku, John, Hao, Jia, Gao, Xiumei, Chang, Yanxu, He, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778862/
https://www.ncbi.nlm.nih.gov/pubmed/31662775
http://dx.doi.org/10.1155/2019/5242605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778862/
https://www.ncbi.nlm.nih.gov/pubmed/31662775
http://dx.doi.org/10.1155/2019/5242605

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