Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells

Drug resistance to temozolomide (TMZ) contributes to the majority of tumor recurrence and treatment failure in patients with glioblastoma multiforme (GBM). Autophagy has been reported to play a role in chemoresistance in various types of cancer, including GBM. The anticancer effect of statins is aro...

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Detalles Bibliográficos
Autores principales: Zhu, Zhiyuan, Zhang, Pingde, Li, Ning, Kiang, Karrie Mei Yee, Cheng, Stephen Yin, Wong, Vincent Kam-Wai, Leung, Gilberto Ka-Kit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778891/
https://www.ncbi.nlm.nih.gov/pubmed/31662972
http://dx.doi.org/10.1155/2019/2710693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778891/
https://www.ncbi.nlm.nih.gov/pubmed/31662972
http://dx.doi.org/10.1155/2019/2710693

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