Polymer Masked–Unmasked Protein Therapy: Identification of the Active Species after Amylase Activation of Dextrin–Colistin Conjugates

[Image: see text] Polymer masked–unmasked protein therapy (PUMPT) uses conjugation of a biodegradable polymer, such as dextrin, hyaluronic acid, or poly(l-glutamic acid), to mask a protein or peptide’s activity; subsequent locally triggered degradation of the polymer at the target site regenerates b...

Descripción completa

Detalles Bibliográficos
Autores principales: Varache, Mathieu, Powell, Lydia C., Aarstad, Olav A., Williams, Thomas L., Wenzel, Margot N., Thomas, David W., Ferguson, Elaine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779022/
https://www.ncbi.nlm.nih.gov/pubmed/31125239
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779022/
https://www.ncbi.nlm.nih.gov/pubmed/31125239
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00393

Ejemplares similares