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Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform
Ligand binding to death receptors activates apoptosis in cancer cells. Stimulation of death receptors results in the formation of intracellular multiprotein platforms that either activate the apoptotic initiator Caspase-8 to trigger cell death, or signal through kinases to initiate inflammatory and...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779275/ https://www.ncbi.nlm.nih.gov/pubmed/31553717 http://dx.doi.org/10.1371/journal.pcbi.1007374 |