A Hyperactive Form of unc-13 Enhances Ca(2+) Sensitivity and Synaptic Vesicle Release Probability in C. elegans

Munc13 proteins play several roles in regulating shortterm synaptic plasticity. However, the underlying molecular mechanisms remain largely unclear. Here we report that C. elegans UNC-13L, a Munc13-1 ortholog, has three domains that inhibit synaptic vesicle (SV) exocytosis. These include the X (sequ...

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Detalles Bibliográficos
Autores principales: Li, Lei, Liu, Haowen, Hall, Qi, Wang, Wei, Yu, Yi, Kaplan, Joshua M., Hu, Zhitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779330/
https://www.ncbi.nlm.nih.gov/pubmed/31509756
http://dx.doi.org/10.1016/j.celrep.2019.08.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779330/
https://www.ncbi.nlm.nih.gov/pubmed/31509756
http://dx.doi.org/10.1016/j.celrep.2019.08.018

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