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A Hyperactive Form of unc-13 Enhances Ca(2+) Sensitivity and Synaptic Vesicle Release Probability in C. elegans
Munc13 proteins play several roles in regulating shortterm synaptic plasticity. However, the underlying molecular mechanisms remain largely unclear. Here we report that C. elegans UNC-13L, a Munc13-1 ortholog, has three domains that inhibit synaptic vesicle (SV) exocytosis. These include the X (sequ...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779330/ https://www.ncbi.nlm.nih.gov/pubmed/31509756 http://dx.doi.org/10.1016/j.celrep.2019.08.018 |