Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma

Multiple myeloma (MM) drug resistance highlights a need for alternative therapeutic strategies. In this study, we show that CASIN, a selective inhibitor of cell division cycle 42 (Cdc42) GTPase, inhibited proliferation and survival of melphalan/bortezomib-resistant MM cells more profoundly than that...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Phuong, Chakrabarti, Jayati, Li, Yuan, Kalim, Khalid W., Zhang, Mengnan, Zhang, Lin, Zheng, Yi, Guo, Fukun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779689/
https://www.ncbi.nlm.nih.gov/pubmed/31632904
http://dx.doi.org/10.3389/fonc.2019.00958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779689/
https://www.ncbi.nlm.nih.gov/pubmed/31632904
http://dx.doi.org/10.3389/fonc.2019.00958

Ejemplares similares