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Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779829/ https://www.ncbi.nlm.nih.gov/pubmed/31632267 http://dx.doi.org/10.3389/fphar.2019.01110 |
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author | Nie, Xiaobo Xia, Fulin Liu, Ying Zhou, Yun Ye, Wenling Hean, Panha Meng, Jiming Liu, Huiyang Liu, Lei Wen, Jianxun Ren, Xuequn Chen, Wei-Dong Wang, Yan-Dong |
author_facet | Nie, Xiaobo Xia, Fulin Liu, Ying Zhou, Yun Ye, Wenling Hean, Panha Meng, Jiming Liu, Huiyang Liu, Lei Wen, Jianxun Ren, Xuequn Chen, Wei-Dong Wang, Yan-Dong |
author_sort | Nie, Xiaobo |
collection | PubMed |
description | The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC cells delayed tumor formation in nude mouse xenografts through silencing of canonical Wnt pathway and glycolysis. We further found that silencing of Wnt3 enhanced the sensitivity of CRC cells to cisplatin through inducing apoptotic cell death. Taken together, it demonstrates that Wnt3 is a novel clinical biomarker for the detection of CRC and plays an important role in colorectal tumorigenesis. Therefore, downregulation of Wnt3 will be a valuable strategy in CRC treatment. |
format | Online Article Text |
id | pubmed-6779829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67798292019-10-18 Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration Nie, Xiaobo Xia, Fulin Liu, Ying Zhou, Yun Ye, Wenling Hean, Panha Meng, Jiming Liu, Huiyang Liu, Lei Wen, Jianxun Ren, Xuequn Chen, Wei-Dong Wang, Yan-Dong Front Pharmacol Pharmacology The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC cells delayed tumor formation in nude mouse xenografts through silencing of canonical Wnt pathway and glycolysis. We further found that silencing of Wnt3 enhanced the sensitivity of CRC cells to cisplatin through inducing apoptotic cell death. Taken together, it demonstrates that Wnt3 is a novel clinical biomarker for the detection of CRC and plays an important role in colorectal tumorigenesis. Therefore, downregulation of Wnt3 will be a valuable strategy in CRC treatment. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6779829/ /pubmed/31632267 http://dx.doi.org/10.3389/fphar.2019.01110 Text en Copyright © 2019 Nie, Xia, Liu, Zhou, Ye, Hean, Meng, Liu, Liu, Wen, Ren, Chen and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Nie, Xiaobo Xia, Fulin Liu, Ying Zhou, Yun Ye, Wenling Hean, Panha Meng, Jiming Liu, Huiyang Liu, Lei Wen, Jianxun Ren, Xuequn Chen, Wei-Dong Wang, Yan-Dong Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration |
title | Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration |
title_full | Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration |
title_fullStr | Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration |
title_full_unstemmed | Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration |
title_short | Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration |
title_sort | downregulation of wnt3 suppresses colorectal cancer development through inhibiting cell proliferation and migration |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779829/ https://www.ncbi.nlm.nih.gov/pubmed/31632267 http://dx.doi.org/10.3389/fphar.2019.01110 |
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