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Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration

The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC...

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Autores principales: Nie, Xiaobo, Xia, Fulin, Liu, Ying, Zhou, Yun, Ye, Wenling, Hean, Panha, Meng, Jiming, Liu, Huiyang, Liu, Lei, Wen, Jianxun, Ren, Xuequn, Chen, Wei-Dong, Wang, Yan-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779829/
https://www.ncbi.nlm.nih.gov/pubmed/31632267
http://dx.doi.org/10.3389/fphar.2019.01110
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author Nie, Xiaobo
Xia, Fulin
Liu, Ying
Zhou, Yun
Ye, Wenling
Hean, Panha
Meng, Jiming
Liu, Huiyang
Liu, Lei
Wen, Jianxun
Ren, Xuequn
Chen, Wei-Dong
Wang, Yan-Dong
author_facet Nie, Xiaobo
Xia, Fulin
Liu, Ying
Zhou, Yun
Ye, Wenling
Hean, Panha
Meng, Jiming
Liu, Huiyang
Liu, Lei
Wen, Jianxun
Ren, Xuequn
Chen, Wei-Dong
Wang, Yan-Dong
author_sort Nie, Xiaobo
collection PubMed
description The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC cells delayed tumor formation in nude mouse xenografts through silencing of canonical Wnt pathway and glycolysis. We further found that silencing of Wnt3 enhanced the sensitivity of CRC cells to cisplatin through inducing apoptotic cell death. Taken together, it demonstrates that Wnt3 is a novel clinical biomarker for the detection of CRC and plays an important role in colorectal tumorigenesis. Therefore, downregulation of Wnt3 will be a valuable strategy in CRC treatment.
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spelling pubmed-67798292019-10-18 Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration Nie, Xiaobo Xia, Fulin Liu, Ying Zhou, Yun Ye, Wenling Hean, Panha Meng, Jiming Liu, Huiyang Liu, Lei Wen, Jianxun Ren, Xuequn Chen, Wei-Dong Wang, Yan-Dong Front Pharmacol Pharmacology The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC cells delayed tumor formation in nude mouse xenografts through silencing of canonical Wnt pathway and glycolysis. We further found that silencing of Wnt3 enhanced the sensitivity of CRC cells to cisplatin through inducing apoptotic cell death. Taken together, it demonstrates that Wnt3 is a novel clinical biomarker for the detection of CRC and plays an important role in colorectal tumorigenesis. Therefore, downregulation of Wnt3 will be a valuable strategy in CRC treatment. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6779829/ /pubmed/31632267 http://dx.doi.org/10.3389/fphar.2019.01110 Text en Copyright © 2019 Nie, Xia, Liu, Zhou, Ye, Hean, Meng, Liu, Liu, Wen, Ren, Chen and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Nie, Xiaobo
Xia, Fulin
Liu, Ying
Zhou, Yun
Ye, Wenling
Hean, Panha
Meng, Jiming
Liu, Huiyang
Liu, Lei
Wen, Jianxun
Ren, Xuequn
Chen, Wei-Dong
Wang, Yan-Dong
Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
title Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
title_full Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
title_fullStr Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
title_full_unstemmed Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
title_short Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration
title_sort downregulation of wnt3 suppresses colorectal cancer development through inhibiting cell proliferation and migration
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779829/
https://www.ncbi.nlm.nih.gov/pubmed/31632267
http://dx.doi.org/10.3389/fphar.2019.01110
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