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LUF7244, an allosteric modulator/activator of K(v)11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model
BACKGROUND AND PURPOSE: K(v)11.1 (hERG) channel blockade is an adverse effect of many drugs and lead compounds, associated with lethal cardiac arrhythmias. LUF7244 is a negative allosteric modulator/activator of K(v)11.1 channels that inhibits early afterdepolarizations in vitro. We tested LUF7244 f...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780032/ https://www.ncbi.nlm.nih.gov/pubmed/31339551 http://dx.doi.org/10.1111/bph.14798 |