LUF7244, an allosteric modulator/activator of K(v)11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

BACKGROUND AND PURPOSE: K(v)11.1 (hERG) channel blockade is an adverse effect of many drugs and lead compounds, associated with lethal cardiac arrhythmias. LUF7244 is a negative allosteric modulator/activator of K(v)11.1 channels that inhibits early afterdepolarizations in vitro. We tested LUF7244 f...

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Detalles Bibliográficos
Autores principales: Qile, Muge, Beekman, Henriette D.M., Sprenkeler, David J., Houtman, Marien J.C., van Ham, Willem B., Stary‐Weinzinger, Anna, Beyl, Stanislav, Hering, Steffen, van den Berg, Dirk‐Jan, de Lange, Elizabeth C.M., Heitman, Laura H., IJzerman, Ad P., Vos, Marc A., van der Heyden, Marcel A.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780032/
https://www.ncbi.nlm.nih.gov/pubmed/31339551
http://dx.doi.org/10.1111/bph.14798

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